| Primary information |
|---|
| ID | antitb_1454, |
| Name | 25809751 |
| N-Terminal modification | A24-ESAT6 |
| C-Terminal Modification | AYQGVQQKW |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 9 |
| Source | L |
| Species | Protein derived |
| Strain | MTB derived protein ESAT6 |
| Inhibition Concentration | Mycobacterium tuberculosis |
| In Vitro/ In vivo | Mycobacterium tuberculosis Rv |
| Sequence | 2104 |
| Cytotoxicity | NA |
| In vivo Model | NA |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | IL7Rα expression reduced and CD107a expression also decreased among CD8+ T cell after post TB treatment |
| Combination Therapy | Drug treatement of TB with antiTB drug found to decrease the frequency of MTB Antigen CD8+ T-cell, so evaluation of these antigenic peptide after TB treatment serve as a valuable marker for the evaluation of TB therapy. |
| Other activities | CD8+ T-cell |
| PMID | NA |
| Year of Publication | NA |
Tertiary Structure
(Technique) | Not Predicted), |
| Primary information |
|---|
| ID | antitb_1728, |
| Name | US 2002/013197 |
| N-Terminal modification | SEQ ID NO 10 |
| C-Terminal Modification | AYQGVQQKW |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 9 |
| Source | L |
| Species | Protein Derived |
| Strain | From the proetins containing mycobacterial CD8 T cell epitopes |
| Inhibition Concentration | Mycobacterium tuberculosis |
| In Vitro/ In vivo | Mycobacterium tuberculosis |
| Inhibition Concentration | In vitro |
| Sequence | 2002 |
| Cytotoxicity | PBMcs |
| In vivo Model | NA |
| Lethal Dose | NA |
| Immune Responce | β2-microglobulin gene knowckout mice, TAP-1 null mutant mice and HSP-65 immunized mice |
| Mechanism of Action | NA |
| Target | IFN-γ release increases |
| Combination Therapy | By CD8 T cell response |
| Other activities | NA |
| PMID | None |
| Year of Publication | None |
Tertiary Structure
(Technique) | Not Predicted), |